Hydrochloric Acid → HCID 20719101, compound

Participants

Reaction Steps

12.5 g (0.05 mol) of Cbz-Pro are dissolved in 70 cc of THF and 7.5 cc (0.05 mol) of Et3N, and then cooled to -10° C. 6.8 g (0.05 mol) of isobutyl chloroformate in 30 cc of THF are added dropwise, whereafter the mixture is stirred for 20 minutes at <10° C. A solution of 7.9 g (0.06 mol) of Leu and 12.6 cc (0.08 mol) of Et3N in 65 cc of water are added to the mixture and the reaction is allowed to continue for 90 minutes, allowing the temperature to rise to 20° C. The reaction mixture is acidified with 6N-HCl, the THF is removed under vacuum and the solid which is obtained is dissolved in 20 cc of AcOH and then precipitated with 200 cc of water. Recrystallisation takes place in CCl4. The product indicated in the heading is obtained, this having two melting points: either 118° C. or 136° C.

Provenance & Evidence