Sodium Hydroxide → HCID 20564185, compound

HRID 848739Notes

Reaction equation

HRID 848739 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:19][C:12]3[NH:13][C:14](=[S:18])[NH:15][C:16](=[O:17])[C:11]=3[CH2:10][C:9]=2[CH:20]=1)=[O:4].[OH-].[Na+]>>[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:19][C:12]3[NH:13][C:14](=[S:18])[NH:15][C:16](=[O:17])[C:11]=3[CH2:10][C:9]=2[CH:20]=1)([OH:4])=[O:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 20564259HCID 20564259, compound

Product 1

HCID 20564185HCID 20564185, compound

Procedure

Warm a suspension of 7-methoxycarbonyl-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione (5 g.) in 1 N-sodium hydroxide (25 ml.) until a clear solution is formed and continue the warming for an additional 1/2 hour. Filter the solution and acidify the filtrate with 2 N sulfuric acid. Filter and wash the solids with water, isopropanol and then ether. Dry the washed solid to obtain. 7-carboxy-2,4-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione.

Workup

  1. temperatureWarm
  2. customis formed
  3. customwarming for an additional 1/2 hour
  4. filtrationFilter the solution
  5. filtrationFilter
  6. washwash the solids with water, isopropanol
  7. customDry the washed solid
  8. customto obtain

Sources & evidence

ORD record
ord-1a2b304f5b2c4c7c9768c305baf25ec3
Source dataset
uspto-grants-1981_10
Patent number
US04297355

Reaction notes

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