Water → HCID 54457780, compound

Participants

Reaction Steps

2 g of anhydrous potassium tert.-butylate are added to a solution of 2.5 g of N-(5-acetyl-8-methoxyquinolin-6-yl)oxamide acid methyl ester in 50 ml of anhydrous N,N-dimethylformamide and the whole is heated, with the exclusion of water, for 10 hours at 130°. The solution is then allowed to cool and is evaporated to dryness in vacuo. The residue is treated in succession with 2 N acetic acid and water. By chromatographic purification on silica gel and fractionated crystallisation from N,N-dimethylformamide, the 6-methyoxy-1-oxo-1,4-dihydro-4,7-phenanthroline-3-carboxylic acid methyl ester having a melting point of 280° (with decomposition) is obtained.

Provenance & Evidence