Water → HCID 86738072, compound

Participants

Reaction Steps

30 ml of oxalic acid diethyl ester are added to a solution of 10 g of 5-acetyl-6-nitro-8-methoxyquinoline in 200 ml of ethanol and 3 g of sodium ethylate, and refluxed, whilst stirring, for 12 hours with the exclusion of water. 100 ml of toluene are then added and the reaction mixture is heated for a further 5 hours, then evaporated to dryness in vacuo and the residue triturated first with 2 N acetic acid then with water. The crude 4-(6-nitro-8-methoxyquinolin-6-yl)-2,4-dioxobutyric acid ethyl ester obtained in this manner is further processed without further purification.

Provenance & Evidence