Hydrochloric Acid → HCID 20564369, compound

Participants

Reaction Steps

While stirring, 22.3 g of diisopropylamine is dripped into a solution of 24.5 g of α-chloro-α-(4-chlorophenyl)-acetyl chloride (see a)) in 50 ml of dioxane. After the exothermic reaction has subsided, the mixture is stirred overnight and then poured into 700 ml of ice water; the resultant mixture is acidified with dilute hydrochloric acid and the oil which separates out is extracted 8 times, each time with 100 ml of dichloromethane. The combined extracts are washed twice with sodium carbonate solution, dried over magnesium sulfate and concentrated. There is obtained 27.2 g of α-chloro-α-(4-chlorophenyl)-acetic acid diisopropyl amide as a brownish oil.

Provenance & Evidence