反应详情

2β-Ethyl-17β-methoxy-5α-androstan-3-one (Step A) is dissolved in ethanol (95%, 13 ml.) followed by addition of sodium hydroxide (50%, 14 drops). After stirring at 20°-25° for 4.5 hrs. the mixture is extracted with diethyl ether, the diethyl ether extract is concentrated under reduced pressure to yield the title compound, which is recrystallized twice from methanol; m.p. 105°-107°; NMR (CDCl3) 0.77, 1.05, 3.20 and 3.33 δ.

1. extractionthe mixture is extracted with diethyl ether
2. extractionthe diethyl ether extract
3. concentrationis concentrated under reduced pressure