Water → HCID 86738082, compound

Participants

Reaction Steps

A mixture of 17β-methoxy-2α-methyl-5α-androstan-3-one (Acta. Endocrinology 36, 83 (1961), 0.5 g.), hydroxylamine hydrochloride (0.218 g.) and sodium acetate (0.258 g.) in ethanol (20 ml.) is refluxed for 1 hour. Water is then added; a precipitate forms which is filtered, washed, dried and recrystallized from methylene chloride-acetone to give the title compound, m.p. 203°-211°; IR (mull) 3360 and 1650 cm-1 ; MS (me) 333; NMR (CDCl3) 0.75, 0.93, 1.06, 3.15 and 3.33 δ.

Provenance & Evidence