Methanesulfonic Acid → HCID 178442894, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 13.9 g of 2-chloro-5-(3-octadecylimidazolidin-2-on-1-yl)aniline, 9.3 g of 3-ethoxy-1-(2,4,6-trichlorophenyl)-2-pyrazolin-5-one and 1 g of methanesulfonic acid was heated at 150° C. under reduced pressure with stirring for 6 hours. After cooling, the reaction mixture was dissolved in ethyl acetate and washed three times with water. After distilling off the solvent, the residue was separated by a silica gel chromatography (using a solvent mixture of ethyl acetate and benzene as a spreading agent) to obtain the desired compound. By recrystallization from a solvent mixture of ethyl acetate and acetonitrile 10.5 g of the crystals having a melting point of 163° to 168° C. were obtained.

Provenance & Evidence