HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → 7-Isothiocyanatobenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | Benzofuran-7-amine | HCID 11217277 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 7-Isothiocyanatobenzofuran | HCID 13035277 | — |
Reaction Steps
7-Amino-benzo[b]furan is reacted with thiophosgene in 3 N hydrochloric acid at room temperature over 1 hour to give 7-isothiocyanatobenzo[b]furan. (M.Pt. 45°-46° from petroleum ether.) Reaction of this isothiocyanate with ethanolamine in ether gives N-benzo[b]furan-7-yl-N'-2-hydroxyethylthiourea (m.pt. 138°-139° from methanol) which is used further in the crude state.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04297490 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-de60e94b7312446a8c937ef65e6104c9 |
| Source note | uspto-grants-1981_10 |