3,3-Dimethyl-12-isopropyl-1-aza-1,5,9-cyclododecatriene → 3,3-Dimethyl-12-isopropyl-1-aza-cyclododecane

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Reaction Steps

466.8 g (2 mols) of 3,3-dimethyl-12-isopropyl-1-aza-1,5,9-cyclododecatriene is dissolved in 4 liters of cyclohexane, and the solution is hydrogenated at 20°-25° C. under an initial pressure of 100 bars, in the presence of 80 g of rhodium/aluminium oxide, for 4 hours in a steel autoclave. The solvent is then distilled off to obtain, as main fraction, 425 g 1.79 mols) of 3,3-dimethyl-12-isopropyl-1-aza-cyclododecane; b.p. 92°-94° C./4 Pa; nD20 =1.4706.

Provenance & Evidence