N-[4,5-Dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1H-pyrazol-3-yl]-N-propyl-3-nitrobenzamide → N-[4,5-Dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1H-pyrazol-3-yl]-N-propyl-3-aminobenzamide

Participants

Reaction Steps

N-[4,5-Dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1H-pyrazol-3-yl]-N-propyl-3-nitrobenzamide (33.0 g, 68.3 mmol) was dissolved in glacial acetic acid (300 ml) and 10% palladium on charcoal (3.2 g) was added. The mixture was hydrogenated under pressure (30 atms) for 4 hrs, then the catalyst was removed by filtration through Kieselguhr. The solvent was removed by evaporation and the product was dried under vacuum to give a white glass, 32.5 g, ca 100%. The product was used in the next stage without purification.

Provenance & Evidence