HCID 53900518, compound → HCID 9801620, compound

Participants

Reaction Steps

##STR41## A solution of 5-[4-[2-[4-methyl-1-oxo-1,2-dihydro-phthalazin-2-yl]ethoxy]phenyl methylene] thiazolidin-2,4-dione (9.0 g, 22.0 mmoles) obtained in example 1, in 1,4-dioxane (500 mL) was reduced with hydrogen in the presence of 10% palladium on charcoal (22.5 g) at 60 psi for 48 h. The mixture was filtered through a bed of celite. The filtrate was evaporated to dryness under reduced pressure. The crude compound was recrystallised using CH2Cl2 /pet. ether to afford the title compound (7.2 g, 80%). mp: 170° C.

Provenance & Evidence