Water → HCID 19369858, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromomethyl-2,3-dihydro-6,7-dimethoxy-2,4-dimethylbenzofuran-5-ol (1.2 g), 4-phenylpiperidine (1.2 g) and triethylamine (1.1 ml) was stirred at under an atmosphere of argon in a sealed tube at 180° C. for 16 hours. After the reaction mixture was cooled, water, triethylamine and ethyl acetate were added, and the mixture was shaken. The organic layer was separated, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=4:1) to obtain the title compound (0.6 g, 40%).

Provenance & Evidence