HCID 54084144, compound → HCID 18800733, compound

HRID 849050Notes

Reaction equation

HRID 849050 reaction equation
[C:1]1([CH:7]=[CH:8][CH2:9][CH:10]2[NH:16][C:15](=[O:17])[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[C:1]1([CH2:7][CH2:8][CH2:9][CH:10]2[NH:16][C:15](=[O:17])[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 54084144HCID 54084144, compound

Product 1

HCID 18800733HCID 18800733, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The title material of Example 32 (0.46 g, 2.0 mmol) in MeOH and 4% Pd on carbon (0.10 g) were combined in a standard Parr apparatus (125 mL bottle). The hydrogenation was carried out at room temperature under a H2 pressure of 5 psi for 1 hr. All solvent was then removed under reduced pressure to yield 0.50 (09%) of the title material as a white semi-solid.

Workup

  1. customwas carried out at room temperature under a H2
  2. customfor 1 hr
  3. customAll solvent was then removed under reduced pressure

Sources & evidence

ORD record
ord-f0a888963ef647c2b390f93c16c48191
Source dataset
uspto-grants-2000_01
Patent number
US06011028

Reaction notes

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