HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 84913Generated: October 29, 2026
Diisopropylethylamine → (R)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate
https://huagongshe.com/reaction/84913
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,6-Dichloro-5-fluoronicotinamide | HCID 2774022 | — |
| Reactant | (R)-benzyl-1-(1-aminopropyl)cyclopropylcarbamate hydrochloride | HCID 86666166 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | (R)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate | HCID 86666165 | 44.8% |
Reaction Steps
To a solution of 2,6-dichloro-5-fluoronicotinamide (233 mg, 1.22 mmol) in NMP (5.0 mL) was added (R)-benzyl-1-(1-aminopropyl)cyclopropylcarbamate hydrochloride salt (350 mg, 1.23 mmol) and DIPEA (0.434 mL, 2.44 mmol). After heated at 80° C. for 4 h, the mixture was diluted with EtOAc, organic layer was washed brine, dried and concentrated to give (R)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate (220 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08846928B2 |
|---|
| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-0957c8a2e40c42bdae5a729a46b38a97 |
|---|
| Source note | uspto-grants-2014_09 |
|---|
