HCID 178418361, compound → HCID 178478658, compound

HRID 849152Notes

Reaction equation

HRID 849152 reaction equation
[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]2[NH:18][C:17](=[NH:19])[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][CH:6]=1)([O-])=O.[H][H]>CCO.[Pd]>[ClH:1].[ClH:1].[NH:19]=[C:17]1[NH:18][CH:12]([CH2:11][C:8]2[CH:7]=[CH:6][C:5]([NH2:2])=[CH:10][CH:9]=2)[CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178479050HCID 178479050, compound

Product 1

HCID 178478658HCID 178478658, compoundYield 176.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The product from Example 273 (0.55 g, 1.8 mmol) in 30 mL of EtOH was reduced with 5% Palladium on carbon under 5 psi of hydrogen. Solvent removal in vacuo followed by lyophilization in water gave 0.46 g (97%) of the title material.

Workup

  1. customSolvent removal in vacuo

Sources & evidence

ORD record
ord-be7a99ee343a45ea9f411785f096eb0b
Source dataset
uspto-grants-2000_01
Patent number
US06011028

Reaction notes

Loading…