HCID 53962869, compound → HCID 19369278, compound

Participants

Reaction Steps

Example 296 A) A sample of the Hexahydro-7-[2-(2-pyridyl) ethyl]-1H-azepin-2-one product of Example 290b (2.4 g, 11 mmol), platinum oxide (500 mg) and glacial acetic acid (30 mL) were shaken on a Parr hydrogenator at 55 psi of hydrogen overnight. The contents were filtered and the filtrate was concentrated in vacuo. The residue was dissolved in water and adjusted to pH 9 with 2.5N NaOH. The aqueous solution was extracted with CH2Cl2 and the organic layer was dried over MgSO4 and concentrated in vacuo leaving hexahydro-7-[2-(2-piperidyl)ethyl]-1H-azepin-2-one as a white solid (2.3 g).

Provenance & Evidence