Pyridine → HCID 19369246, compound

Participants

Reaction Steps

Example 296 B) To the hexahydro-7-[2-(2-piperidyl) ethyl]-1H-azepin-2-one product of Example 296 A (2-3 g, 10 mmol) in anhydrous pyridine (8 mL) and CH2Cl2 (4 mL) was added dropwise methanesulfonyl chloride (0.74 mL) in CH2Cl2 (2 mL). The contents were stirred overnight, concentrated in vacuo and partitioned between CH2Cl2 and water. The CH2Cl2 layer was dried over MgSO4 and concentrated in vacuo leaving an oil. The oil was purified by C18 reverse phase chromatography eluding with a CH3CN/H2O (0.05% TFA) gradient to give hexahydro-7-[2-(2-methylsulfonylpiperidyl)ethyl]-1H-azepin-2-one (1.5 g).

Provenance & Evidence