HCID 17872147, compound → HCID 19369828, compound

HRID 849172Notes

Reaction equation

HRID 849172 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH:10]=[CH:9]1>C(CN)O>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12]([NH:13][CH2:14][CH2:15][OH:21])[C:11]=2[CH:10]=[CH:9]1

Participants

3

Reactant 1

HCID 17872147HCID 17872147, compound

Product 1

HCID 19369828HCID 19369828, compoundYield 144%

Reagents, catalysts & solvents 1

HCID 700EthanolamineSolvent

Procedure

1-(2-Methylphenyl)-4-chloro-6-trifluoromethoxypyrrolo[3,2-c]quinoline(377 mg, 1.0 mmol) was dissolved in ethanolamine(10 ml) in the pressure tube, then reacted at the same condition of Step 3 in the Example 6 to obtain 289 mg of desired compound as solid in 72% of yield.

Workup

  1. customreacted at the same condition of Step 3 in the Example 6

Sources & evidence

ORD record
ord-6b5a362c61144b8089a03dc168fc77d0
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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