HCID 19369780, compound → HCID 19369777, compound

HRID 849191Notes

Reaction equation

HRID 849191 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH:11]=[CH:10]1>C(CN)O>[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][C:23]([F:26])([F:25])[F:24])[C:15]=3[N:14]=[C:13]([NH:14][CH2:15][CH2:16][OH:22])[C:12]=2[CH:11]=[CH:10]1

Participants

3

Reactant 1

HCID 19369780HCID 19369780, compound

Product 1

HCID 19369777HCID 19369777, compoundYield 228%

Reagents, catalysts & solvents 1

HCID 700EthanolamineSolvent

Procedure

1-(2-Methyl-4-fluorophenyl)-4-chloro-6-trifluoromethoxypyrrolo[3,2-c]quinoline(394 mg, 1.0 mmol) was dissolved in ethanolamine(5 ml) in the pressure tube, and reacted at the same condition of Step 3 in the Example 20 to obtain 478 mg of desired compound as solid in 90% of yield.

Workup

  1. customreacted at the same condition of Step 3 in the Example 20

Sources & evidence

ORD record
ord-753e1b14782846dfad392e1db18f9eac
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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