HCID 19369789, compound → HCID 19369790, compound

HRID 849199Notes

Reaction equation

HRID 849199 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH2:10][CH2:9]1>C(CN)O>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])[C:14]=3[N:13]=[C:12]([NH:13][CH2:14][CH2:15][OH:21])[C:11]=2[CH2:10][CH2:9]1

Participants

3

Reactant 1

HCID 19369789HCID 19369789, compound

Product 1

HCID 19369790HCID 19369790, compoundYield 180.2%

Reagents, catalysts & solvents 1

HCID 700EthanolamineSolvent

Procedure

1-(2-Methylphenyl)-4-chloro-6-β,β,β-trifluoroethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(500 mg, 1.3 mmol) was dissolved in ethanolamine(5.0 ml), and reacted at the same condition of Step 6 in the Example 30 to obtain 489 mg of desired compound as solid in 92% of yield.

Workup

  1. customreacted at the same condition of Step 6 in the Example 30

Sources & evidence

ORD record
ord-48957165806244f78e3a5fde5361510a
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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