4-Amino-1-butanol → HCID 19369823, compound

HRID 849201Notes

Reaction equation

HRID 849201 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH2:10][CH2:9]1.[NH2:28][CH2:29][CH2:30][CH2:31][CH2:32][OH:33]>C(O)COCCO>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])[C:14]=3[N:13]=[C:12]([NH:28][CH2:29][CH2:30][CH2:31][CH2:32][OH:33])[C:11]=2[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 258684-Amino-1-butanolHCID 19369789HCID 19369789, compound

Product 1

HCID 19369823HCID 19369823, compoundYield 85.5%

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

1-(2-Methylphenyl)-4-chloro-6-β,β,β-trifluoroethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(500 mg, 1.3 mmol) was dissolved in diethylene glycol(10 ml), then hereto was added 4-amino-1-butanol(175 μl, 1.9 mmol), and reacted at the same condition of Step 6 in the Example 30 to obtain 495 mg of desired compound as solid in 87% of yield.

Workup

  1. customreacted at the same condition of Step 6 in the Example 30

Sources & evidence

ORD record
ord-f729515cc8b547eb8108c6bcc4cf37a4
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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