4-Amino-1-butanol → HCID 19369786, compound

HRID 849213Notes

Reaction equation

HRID 849213 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]=3[N:14]=[C:13](Cl)[C:12]=2[CH2:11][CH2:10]1.[NH2:29][CH2:30][CH2:31][CH2:32][CH2:33][OH:34]>C(O)COCCO>[CH3:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]=3[N:14]=[C:13]([NH:29][CH2:30][CH2:31][CH2:32][CH2:33][OH:34])[C:12]=2[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 258684-Amino-1-butanolHCID 19369782HCID 19369782, compound

Product 1

HCID 19369786HCID 19369786, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

1-(2-Methyl-4-fluorophenyl)-4-chloro-6-β,β,β-trifluoroethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(600 mg, 1.4 mmol) was dissolved in diethylene glycol(10 ml) and 4-amino-1-butanol(4 ml) was added. The reaction mixture was reacted at the same condition of Step 3 in the Example 42 to obtain 550 mg of desired compound as solid in 86% of yield.

Workup

  1. customThe reaction mixture was reacted at the same condition of Step 3 in the Example 42

Sources & evidence

ORD record
ord-b2c3f6ee6b4749f29c6d058ecc8c1491
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

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