HCID 19369840, compound → HCID 19369845, compound

Participants

Reaction Conditions

Reaction Steps

1-(2-Methyl-4-fluorophenyl)-4-chloro-6-β,β,β-trifluoroethoxypyrrolo[3,2-c]quinoline(700 mg, 1.7 mmol), prepared by the procedures of Step 1 and Step 2 in the Example 46, was dissolved in ethanolamine(10 ml) in the pressure tube, and the resultant was refluxed at 180° C. for 3 hours. After removing the excess ethanolamine by distillation under reduced pressure, the residue was diluted in dichloromethane(20 ml), and washed with water(15 ml). The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatography to obtain 600 mg of desired compound as solid in 81% of yield.

Provenance & Evidence