Sodium Bicarbonate → HCID 15434246, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound (18.2 mg) obtained in Example 2 in methylene chloride (0.5 ml), boron tribromide (a 1.0M methylene chloride solution, 0.30 ml) was added at -78° C., and the temperature was raised to about 2° C. over a period of 3.6 hours. Then, a saturated sodium hydrogen carbonate aqueous solution (20 ml) was added thereto. The reaction solution was extracted with ethyl acetate, and the organic layer was washed with a saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by thin layer chromatography for separation (silica gel 60F254, manufactured by Merck Company, chloroform:methanol=10:1) to obtain the above identified compound (14.9 mg) as a colorless oily substance.

Provenance & Evidence