HCID 19369682, compound → HCID 19369587, compound

Participants

Reaction Steps

2-{N-tert-butoxycarbonyl-N-[3-methyl-5-(2-propenyloxycarbonylamino)benzyl]amino}-6-(5-ethyl-1,3,4-thiadiazol-2-ylthiomethyl)-4-morpholinopyridine (92 mg) was dissolved in trifluoroacetic acid (1 ml), followed by stirring at room temperature for one hour. The reaction solution was concentrated under reduced pressure, and the residue was subjected to liquid separation with ethyl acetate-a saturated sodium hydrogen carbonate aqueous solution. The organic layer was washed with a saturated sodium chloride aqueous solution and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/methanol=50/1) to obtain the above identified compound (55 mg) as a pale yellow solid.

Provenance & Evidence