HCID 19369594, compound → HCID 19369622, compound

Participants

Reaction Conditions

Reaction Steps

2-{N-tert-butoxycarbonyl-N-[3-(2-propenyloxycarbonylamino)-5-(2-tetrahydropyranyl)oxymethylbenzyl]amino}-6-(5-ethyl-1,3,4-thiadiazol-2-ylthiomethyl)-4-morpholinopyridine (51 mg) was dissolved in 10% hydrogen chloride-methanol (2 ml), followed by stirring at 60° C. for two hours. After cooling naturally, the reaction solution was diluted with ethyl acetate, washed with a saturated sodium hydrogen carbonate aqueous solution and a saturated sodium chloride aqueous solution and then, dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified by thin layer chromatography for separation (chloroform/methanol=10/1) to obtain the above identified compound (55 mg) as a pale yellow amorphous solid.

Provenance & Evidence