1-Benzofuran-4-carboxylic acid → 2,3-Dihydro-1-benzofuran-4-carboxylic acid

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Reaction Steps

Benzofuran-4-carboxylic acid ##STR37## [Eissenstat, et al, J. Medicinal Chemistry, 38 (16) 3094-3105 (1995)] (10.0 g, 61.7 mmol) was hydrogenated (60 psi) in acetic acid (100 mL) over 10% Pd/C (2 g) for 12 hr. The mixture was filtered and the filtrate was diluted with water (500 mL) to give 2,3-dihydrobenzofuran-4-carboxylic acid as a white powder (8.4 g, 83%). A sample was recrystallized from isopropanol to give fine white needles (mp: 185.5-185.5° C.).

Provenance & Evidence