反应详情

To a 2 gallon Parr vessel was charged Raney®-nickel (77 g, Grace 2800 (water decanted)) and 7 M ammonia in methanol (3 L) and trans-methyl 5-chloro-2-(4-cyano-1-methylpyrrolidin-3-yl)benzoate (152.7 g). The reactor was sealed, purged with nitrogen, then purged with hydrogen and pressurized to 30 psi with hydrogen. After 2 hours, the reaction mixture was filtered through a polypropylene cartridge and rinsed with methanol (1 L). The solvent was removed under vacuum to provide the title compound (crude) used as is in Example 199.

1. customThe reactor was sealed
2. custompurged with nitrogen
3. custompurged with hydrogen
4. filtrationthe reaction mixture was filtered through a polypropylene cartridge
5. washrinsed with methanol (1 L)
6. customThe solvent was removed under vacuum