HCID 53653647, compound → HCID 86755026, compound

HRID 849358Notes

Reaction equation

HRID 849358 reaction equation
C(OC(CN[C@H](C)[C@@H](C1C=CC(OC2C=CC=CC=2)=CC=1)CCC1C=CC=CC=1)=O)(C)(C)C.[CH2:34]([O:41][C:42]([CH2:44][NH:45][C@H:46]([CH3:69])[C@@H:47]([C:56]1[CH:61]=[CH:60][C:59]([O:62][C:63]2[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=2)=[CH:58][CH:57]=1)[CH2:48][CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1)=[O:43])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.O1[C@@H](C(OC(C)(C)C)=O)[C@H](C([O-])=O)OC1(C(OCC)=O)C(OCC)=O.[O:95]1[C@H:99]([C:100]([O:102][C:103]([CH3:106])([CH3:105])[CH3:104])=[O:101])[C@@H:98]([C:107]([O-])=[O:108])[O:97][C:96]1([C:119]([O:121][CH2:122][CH2:123][Si:124]([CH3:127])([CH3:126])[CH3:125])=[O:120])[C:110]([O:112][CH2:113][CH2:114][Si:115]([CH3:118])([CH3:117])[CH3:116])=[O:111]>>[CH2:34]([O:41][C:42]([CH2:44][N:45]([C@H:46]([CH3:69])[C@@H:47]([C:56]1[CH:57]=[CH:58][C:59]([O:62][C:63]2[CH:64]=[CH:65][CH:66]=[CH:67][CH:68]=2)=[CH:60][CH:61]=1)[CH2:48][CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1)[C:107]([C@@H:98]1[C@@H:99]([C:100]([O:102][C:103]([CH3:106])([CH3:105])[CH3:104])=[O:101])[O:95][C:96]([C:119]([O:121][CH2:122][CH2:123][Si:124]([CH3:125])([CH3:126])[CH3:127])=[O:120])([C:110]([O:112][CH2:113][CH2:114][Si:115]([CH3:116])([CH3:118])[CH3:117])=[O:111])[O:97]1)=[O:108])=[O:43])[C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

5

Reactant 4

HCID 53653647HCID 53653647, compoundHCID 53763921HCID 53763921, compoundHCID 86755024HCID 86755024, compoundHCID 86755027HCID 86755027, compound

Product 1

HCID 86755026HCID 86755026, compound

Procedure

The above identified compound was obtained by carrying out the same reaction as in Example 19(1) except that instead of N-(tert-butoxycarbonylmethyl)-{(1R,2R)-1-methyl-2-(4-phenoxyphenyl)-4-phenylbutyl}amine used as the starting material in Example 19(1), N-(benzyloxycarbonylmethyl)-{(1R,2R)-1-methyl-2-(4-phenoxyphenyl)-4-phenylbutyl}amine obtained in Example 52, was used, and instead of 5-tert-butyl 2,2-diethyl (4R,5R)-1,3-dioxolane-2,2,4,5-tetracarboxylate, 5-tert-butyl 2,2-bis{2-(trimethylsilyl)ethyl} (4S,5S)-1,3-dioxolane-2,2,4,5-tetracarboxylate obtained in Example 73, was used.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-4761e998cb974282aeac72e4aabc1305
Source dataset
uspto-grants-2000_01
Patent number
US06011174

Reaction notes

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