HCID 86755029, compound → HCID 57309069, compound

HRID 849359Notes

Reaction equation

HRID 849359 reaction equation
C(O[C:9]([CH2:11][N:12]([C@H](C)[C@@H](C1C=CC(OC2C=CC=CC=2)=CC=1)CCC1C=CC=CC=1)C([C@@H]1[C@@H](C([O-])=O)OC(C(OCC[Si](C)(C)C)=O)(C(OCC[Si](C)(C)C)=O)O1)=O)=O)C1C=CC=CC=1.C([O:69][C:70]([CH2:72][N:73]([C@H:96]([CH3:119])[C@@H:97]([C:106]1[CH:111]=[CH:110][C:109]([O:112][C:113]2[CH:118]=[CH:117][CH:116]=[CH:115][CH:114]=2)=[CH:108][CH:107]=1)[CH2:98][CH2:99][C:100]1[CH:105]=[CH:104][CH:103]=[CH:102][CH:101]=1)[C:74]([C@@H:76]1[C@@H:80]([C:81]([O:83]C(C)(C)C)=[O:82])[O:79][C@:78]([C:93]([O-])=[O:94])([C:88]([O:90]CC)=[O:89])[O:77]1)=[O:75])=[O:71])(C)(C)C>>[C:70]([CH2:72][N:73]([C@H:96]([CH3:119])[C@@H:97]([C:106]1[CH:111]=[CH:110][C:109]([O:112][C:113]2[CH:114]=[CH:115][CH:116]=[CH:117][CH:118]=2)=[CH:108][CH:107]=1)[CH2:98][CH2:99][C:100]1[CH:101]=[CH:102][CH:103]=[CH:104][CH:105]=1)[C:74]([C@@H:76]1[C@@H:80]([C:81]([OH:83])=[O:82])[O:79][C@@:78]([C:93](=[O:94])[NH:12][CH2:11][CH3:9])([C:88]([OH:90])=[O:89])[O:77]1)=[O:75])([OH:69])=[O:71]

Participants

3

Reactant 2

HCID 86755029HCID 86755029, compoundHCID 86755031HCID 86755031, compound

Product 1

HCID 57309069HCID 57309069, compound

Procedure

The above identified compound was obtained by carrying out treatment in the same manner as in Example 25(2) except that instead of 2,2-bis{2-(trimethylsilyl)ethyl} (4S,5S)-4-[N-(benzyloxycarbonylmethyl)-N-{(1R,2R)-1-methyl-2-(4-phenoxyphenyl)-4-phenylbutyl}carbamoyl]-1,3-dioxolane-2,2,5-tricarboxylate, 5-tert-butyl 2-ethyl (2R*,4S,5S)-4-[N-(tert-butoxycarbonylmethyl)-N-{(1R,2R)-1-methyl-2-(4-phenoxyphenyl)-4-phenylbutyl}carbamoyl]-1,3-dioxolane-2,2,5-tricarboxylate obtained in Example 20, was used, and carrying out the same reaction as in Example 21.

Workup

  1. customwas obtained
  2. customthe same reaction as in Example 21

Sources & evidence

ORD record
ord-e115a57d003f4711b02590b57d63a635
Source dataset
uspto-grants-2000_01
Patent number
US06011174

Reaction notes

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