HCID 53763921, compound → HCID 70132202, compound

HRID 849360Notes

Reaction equation

C([O:5][C:6]([CH2:8][NH:9][C@H:10]([CH3:33])[C@@H:11]([C:20]1[CH:25]=[CH:24][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:22][CH:21]=1)[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:7])(C)(C)C.C1(C([O-])=O)CC1(C(OCC)=O)C(OCC)=O.[O:50]1[CH2:54][C@@H:53]([C:55]([O-:57])=O)[O:52][C:51]1([C:63]([O:65][CH2:66][CH3:67])=[O:64])[C:58]([O:60][CH2:61][CH3:62])=[O:59]>>[C:6]([CH2:8][N:9]([C@H:10]([CH3:33])[C@@H:11]([C:20]1[CH:21]=[CH:22][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:24][CH:25]=1)[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:55]([C@@H:53]1[CH2:54][O:50][C:51]([C:63]([O:65][CH2:66][CH3:67])=[O:64])([C:58]([O:60][CH2:61][CH3:62])=[O:59])[O:52]1)=[O:57])([OH:7])=[O:5]

Participants

Reactant 3

HCID 53763921HCID 53763921, compound

HCID 86755032HCID 86755032, compound

HCID 86755033HCID 86755033, compound

Product 1

HCID 70132202HCID 70132202, compound

Procedure

The above identified compound was obtained by the same method as in Example 1 except that instead of N-(tert-butoxycarbonylmethyl)-{(1R,2R)-2-(2-fluoro-4-biphenylyl)-1-methyl-4-phenylbutyl}amine used as the starting material in Example 1, N-(tert-butoxycarbonylmethyl)-{(1R,2R)-1-methyl-2-(4-phenoxyphenyl)-4-phenylbutyl}amine obtained in Example 50, was used, and instead of 2,2-diethyl 1,2,2-cyclopropanetricarboxylate, 2,2,-diethyl (4S)-1,3-dioxolane-2,2,4-tricarboxylate obtained in Example 56, was used.

Sources & evidence

ORD record: ord-afb558a51e3c4a0db67368d3f3a91993
Source dataset: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06011174

Reaction notes

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