Nitroethane → HCID 54092347, compound

HRID 849367Notes

Reaction equation

HRID 849367 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:6]=O.C(N)CCC.[N+:23]([CH2:26][CH3:27])([O-:25])=[O:24]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[C:26]([N+:23]([O-:25])=[O:24])[CH3:27])[CH:8]=[CH:9][C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 6587NitroethaneHCID 8007ButylamineHCID 18433807HCID 18433807, compound

Product 1

HCID 54092347HCID 54092347, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.15 g of 3-methoxy-4-phenoxybenzaldehyde, 96 μl of n-butylamine, 10 ml of nitroethane and 5 ml of toluene were mixed and refluxed under heating for 2 hours. The reaction solution was left to cool to room temperature and then, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=20/1) to obtain 953 mg (yield: 69%) of the above identified compound as a colorless oily substance.

Workup

  1. temperaturerefluxed
  2. temperatureunder heating for 2 hours
  3. waitThe reaction solution was left
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=20/1)
  6. customto obtain 953 mg (yield: 69%) of the

Sources & evidence

ORD record
ord-16d8c96f45744278b330954713edcd90
Source dataset
uspto-grants-2000_01
Patent number
US06011174

Reaction notes

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