(2RS,3SR)-3-(4-phenoxyphenyl)-5-phenylpentan-2-ol → N-(ethoxycarbonylmethyl)-{(1RS,2RS)-2-(3-benzyloxy-4-phenoxyphenyl)-1-methyl-4-phenylbutyl}amine

HRID 849372Notes

Reaction equation

HRID 849372 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][NH:7][C@H:8]([CH3:31])[C@@H:9]([C:18]1[CH:23]=[CH:22][C:21]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:20][CH:19]=1)[CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5])[CH3:2].O(C1C=CC(C(CCC2C=CC=CC=2)C(O)C)=CC=1)C1C=CC=CC=1.[CH2:57]([O:64]C1C=C(C(CCC2C=CC=CC=2)C(O)C)C=CC=1OC1C=CC=CC=1)[C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1>>[CH2:1]([O:3][C:4]([CH2:6][NH:7][CH:8]([CH3:31])[CH:9]([C:18]1[CH:19]=[CH:20][C:21]([O:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[C:22]([O:64][CH2:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)[CH:23]=1)[CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 19591495(2RS,3SR)-3-(4-phenoxyphenyl)-5-phenylpentan-2-olHCID 19591515(2RS,3SR)-3-(3-benzyloxy-4-phenoxyphenyl)-5-phenylpentan-2-olHCID 54550437N-(ethoxycarbonylmethyl)-{(1R,2R)-2-(4-phenoxyphenyl)-1-methyl-4-phenylbutyl}amine

Product 1

HCID 19591456N-(ethoxycarbonylmethyl)-{(1RS,2RS)-2-(3-benzyloxy-4-phenoxyphenyl)-1-methyl-4-phenylbutyl}amine

Procedure

The above identified compound was obtained by carrying out the same reaction as in Example 49(5) and (6) except that instead of (2RS,3SR)-3-(4-phenoxyphenyl)-5-phenylpentan-2-ol used as the starting material in Example 49(2), (2RS,3SR)-3-(3-benzyloxy-4-phenoxyphenyl)-5-phenylpentan-2-ol was used.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-72f00e92efb14b86ae0a0af9cd4742c4
Source dataset
uspto-grants-2000_01
Patent number
US06011174

Reaction notes

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