2-(Tri-n-butylstannyl)thiophene → HCID 178478876, compound

HRID 849391Notes

Reaction equation

HRID 849391 reaction equation
C([Sn](CCCC)(CCCC)[C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)CCC.[ClH:19].Br[C:21]1[CH:22]=[CH:23][C:24]2[N:30]([CH2:31][C:32]3[N:33]=[CH:34][NH:35][CH:36]=3)[CH2:29][CH2:28][N:27]([C:37]([C:39]3[C:48]4[C:43](=[CH:44][CH:45]=[CH:46][CH:47]=4)[CH:42]=[CH:41][CH:40]=3)=[O:38])[CH2:26][C:25]=2[CH:49]=1>>[ClH:19].[ClH:19].[NH:35]1[CH:36]=[C:32]([CH2:31][N:30]2[C:24]3[CH:23]=[CH:22][C:21]([C:6]4[S:7][CH:8]=[CH:9][CH:10]=4)=[CH:49][C:25]=3[CH2:26][N:27]([C:37]([C:39]3[C:48]4[C:43](=[CH:44][CH:45]=[CH:46][CH:47]=4)[CH:42]=[CH:41][CH:40]=3)=[O:38])[CH2:28][CH2:29]2)[N:33]=[CH:34]1

Participants

3

Reactant 2

HCID 27793732-(Tri-n-butylstannyl)thiopheneHCID 1784796677-Bromo-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-4-(1-naphthalenylcarbonyl)-1H-1,4-benzodiazepine, hydrochloride

Product 1

HCID 178478876HCID 178478876, compoundYield 10%

Procedure

Example 39 was prepared as a green solid in 10% yield from Compound A of Example 37 and 2-(tributylstannyl)thiophene as described for Compound B of Example 37.

Sources & evidence

ORD record
ord-99647d34eb3c4cebbfb6602d8bd98620
Source dataset
uspto-grants-2000_01
Patent number
US06011029

Reaction notes

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