反应详情

温度

0 °C

A mixture of Compound B (200 mg, 0.63 mmol), dichloromethane (5 mL), and aqueous sodium hydroxide (1 ml, 1N) was combined and cooled to 0° C. Acetyl chloride (66 mL, 0.94 mmol) was added to the mixture, and after stirring for 2 hour at 0° C. aqueous sodium hydroxide (20 ml, 1N) and dichloromethane (50 mL) were added, followed by extraction with dichloromethane (50 mL). The organic portions were combined, dried (Na2SO4), and concentrated to a crude oil (230 mg, 100%).

1. additionwere added
2. extractionfollowed by extraction with dichloromethane (50 mL)
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated to a crude oil (230 mg, 100%)