(R)-7-cyano-2,3,4,5-tetrahydro-4-(phenylacetyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine → HCID 178504913, compound

HRID 849416Notes

Reaction equation

HRID 849416 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[N:12]([CH2:13][C:14]3[N:15]=[CH:16][N:17](C(OC(C)(C)C)=O)[CH:18]=3)[CH2:11][C@@H:10]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[N:9]([S:33]([CH3:36])(=[O:35])=[O:34])[CH2:8][C:7]=2[CH:37]=1)#[N:2].[SnH3]C1N=[CH:43][CH:42]=[CH:41][N:40]=1.[ClH:45].Cl.Cl.N1C=C(CN2C3C=CC(C4C=NC=CC=4)=CC=3CN(C(=O)C(F)(F)F)C(CC3C=CC=CC=3)C2)N=C1.C(C1C=CC2NC[C@@H](CC3C=CC=CC=3)N(C(=O)CC3C=CC=CC=3)CC=2C=1)#N>>[ClH:45].[ClH:45].[NH:17]1[CH:18]=[C:14]([CH2:13][N:12]2[C:6]3[CH:5]=[CH:4][C:3]([C:1]4[N:2]=[CH:43][CH:42]=[CH:41][N:40]=4)=[CH:37][C:7]=3[CH2:8][N:9]([S:33]([CH3:36])(=[O:35])=[O:34])[CH:10]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:11]2)[N:15]=[CH:16]1

Participants

5

Reactant 4

HCID 53636257(R)-7-cyano-2,3,4,5-tetrahydro-4-(phenylacetyl)-3-(phenylmethyl)-1H-1,4-benzodiazepineHCID 69841490(R)-7-cyano-2,3,4,5-tetrahydro-1-[(((1,1-dimethylethoxy)-carbonyl)-1H-imidazol-4-yl)methyl]-4-(methylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepineHCID 871506562-Stannyl pyrimidineHCID 178478619HCID 178478619, compound

Product 1

HCID 178504913HCID 178504913, compound

Procedure

Example 332 was prepared as a yellow solid from Compound A of Example 231 and 2-stannylpyrimidine as described for Compound B of Example 231 and Compound C of Example 231. MS (M+H)+ 475.

Sources & evidence

ORD record
ord-7e483e887e9045a9a505db4f30b54f34
Source dataset
uspto-grants-2000_01
Patent number
US06011029

Reaction notes

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