Toluene → HCID 19366437, compound

Participants

Reaction Steps

Grignard's reagent prepared from 3-fluorobromobenzene (110 mmol), magnesium (110 mmol), and 100 ml of tetrahydrofuran (hereinafter referred to as THF) was added dropwise to a mixture prepared by adding iron acetylacetone (5 mmol) and 300 ml of dried toluene to the acid chloride (100 mmol) at a temperature lower than -50° C. and stirred for 1 hour at the same temperature. The reaction product thus obtained was added in 200 ml of 6M hydrochloric acid and then extracted with toluene (100 ml×2). Extract was dried with anhydrous magnesium sulfate, the solvent was distilled off, and the residue thus obtained was recrystallized from 50 ml of ethanol to obtain 2-fluoro-4-(1-oxo-2-(4-propylcyclohexyl)ethyl)benzene (75 mmol).

Provenance & Evidence