Iodine → Glutathione Disulfide

HRID 849445Notes

Reaction equation

[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].II>>[O:9]=[C:8]([CH2:7][CH2:6][C@@H:2]([C:3](=[O:5])[OH:4])[NH2:1])[NH:10][C@@H:11]([CH2:12][S:13][S:13][CH2:12][C@@H:11]([C:14](=[O:15])[NH:16][CH2:17][C:18](=[O:20])[OH:19])[NH:10][C:8](=[O:9])[CH2:7][CH2:6][C@@H:2]([C:3](=[O:5])[OH:4])[NH2:1])[C:14](=[O:15])[NH:16][CH2:17][C:18](=[O:20])[OH:19]

Participants

Reactant 2

HCID 807Iodine

HCID 124886Glutathione

Product 1

HCID 65359Glutathione Disulfide

Procedure

One equivalence of glutathione in saline is reacted with excess iodine to give about one-half equalivent of GSSG.

Sources & evidence

ORD record: ord-c1d592544ea94382af8716b1180410c8
Source dataset: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06013632

Reaction notes

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