Sodium Hydroxide → 8-Methyl-2,3-dihydrobenz-1,4-oxathiin-7-carboxylic acid

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Reaction Steps

4.0 g (0.0168 mol) of ethyl 8-methyl-2,3-dihydrobenz-1,4-oxathiin-7-carboxylate are heated to reflux together with 1.0 g (0.0252 mol) of sodium hydroxide in 40 ml of methanol/water. The mixture is stirred for 2 hours at the room temperature and the solvent is then distilled off. The residue is taken up with water. The mixture is extracted with ether and the aqueous phase is then acidified with 2N hydrochloric acid. The useful product precipitates, is filtered off with suction and washed with a little water. The product is dried in a vacuum drying oven at 40° C.

Provenance & Evidence