Methanol → FK 1052

HRID 849463Notes

Reaction equation

HRID 849463 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12.CC1(C)C2(CS(O)(=O)=O)C(CC1CC2)=O.CO.[OH-].[Na+]>O>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 86755043HCID 86755043, compound

Product 1

HCID 125368FK 1052Yield 96%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(+)8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one·CSA salt (100 g) was suspended in the mixture of methanol (300 ml) and deionized water (700 ml), and adjusted to pH11.5-12.5 with 24% aqueous sodium hydroxide, the crystals were collected by filtration, washed with water, and dried to obtain (+)8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one as white crystals.

Workup

  1. filtrationthe crystals were collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-c76786f1496e48b2ae4fa2a9e21dbfa8
Source dataset
uspto-grants-2000_01
Patent number
US06013653

Reaction notes

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