Cyclobutanecarbonyl chloride → HCID 15289311, compound

HRID 849474Notes

Reaction equation

[CH2:1]([CH:10]1[CH2:14][CH2:13][CH2:12][NH:11]1)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:15]1([C:19](Cl)=[O:20])[CH2:18][CH2:17]C1>>[CH2:1]([CH:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:19]([CH:15]1[CH2:18][CH2:17]1)=[O:20])/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 78705Cyclobutanecarbonyl chloride

HCID 53985678HCID 53985678, compound

Product 1

HCID 15289311HCID 15289311, compound

Procedure

Stage a) According to the method of Example 1.1, Stage a), from 2-(cinnamyl)pyrrolidine and cyclobutanecarboxylic acid chloride there is obtained, with a yield of 95%, 2-cinnamyl-1-cyclobutanecarbonylpyrrolidine (formula II; Ar=C6H5, m=1, n=1, R=cyclobutyl), which is introduced in the next stage without further treatment.

Sources & evidence

ORD record: ord-3aa3d67501b84b1f857f085c56e2c734
Source dataset: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06013656

Reaction notes

Loading…