HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(2,4-Dichlorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Benzene, 2,4-dichloro-1-fluoro- | HCID 123112 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-(2,4-Dichlorophenyl)piperazine | HCID 2737527 | — |
Reaction Steps
A mixture of 1,3-dichloro-4-fluorobenzene )Aldrich; 4.21 g), piperazine (Aldrich; 11.0 g), and N,N-dimethylacetamide (Aldrich; 15 mL) is heated at 165° C. for 6.5 h. After cooling, the mixture is partitioned between dichloromethane and aq. sodium bicarbonate. The organic layers are dried over sodium sulfate and concentrated under reduced pressure to give 4.48 g of 1-(2,4-dichlorophenyl)piperazine. 1H NMR (CDCl3) δ 3.00, 3.06, 6.96, 7.19, 7.36.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06013654 |
| Source dataset | uspto-grants-2000_01 |
| ORD ID | ord-887365c05f5c48f6be8cc28983c7d716 |
| Source note | uspto-grants-2000_01 |