HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(5-Chloropyridin-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2,5-Dichloropyridine | HCID 27685 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-(5-Chloropyridin-2-yl)piperazine | HCID 3805301 | 50.2% |
Reaction Steps
Following the general procedure of Example 33, Step 1, and making noncritical variations, 2,5-dichloropyridine (Aldrich; 5.10 g), piperazine (14.8 g), water (50 mL), and N,N-dimethylacetamide (2 mL) give 3.42 g of 1-(5-chloropyridin-2-yl)piperazine; mp 92-107° C.; IR 1480, 1244, 1390, 1589, 815 cm-1 ; 1H NMR (CDCl3) δ 2.98, 3.47, 6.58, 7.42, 8.11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06013654 |
| Source dataset | uspto-grants-2000_01 |
| ORD ID | ord-6e10f499db92499980071410eeb1ec39 |
| Source note | uspto-grants-2000_01 |