Triethylamine → HCID 19366861, compound

Participants

Reaction Steps

Part A: To a solution of 5.2 g (23 mmol) of 3-[(4-methoxyphenyl)sulfonyl]propan-1-ol from Example 13 and 12.6 mL (9.1 g, 90 mmole) of triethylamine in 25 mL of methylene chloride at zero° C., was added a solution of 14.4 g (90 mmol) of sulfur trioxide-pyridine complex in 25 mL of DMSO. After 1 hour, the reaction mixture was added to 200 mL of ice, ethyl acetate was added, the organic layer was separated and washed with water, 5% potassium hydrogen sulfate solution and brine, dried with magnesium sulfate, filtered and concentrated to afford 4.9 g of 3-[(4-methoxyphenyl)sulfonyl]propan-1-al suitable for the next reaction.

Provenance & Evidence