Aluminium lithium hydride → HCID 19366834, compound

Participants

Reaction Steps

Part C: To an ice cooled, stirred solution of (6.2 g, 20 mmol) of β-(4-methoxyphenylsulfonyl)-D,L-alanine methyl ester hydrochloride in tetrahydrofuran under nitrogen was added dropwise, (20 mL, 20 mmol) of lithium aluminum hydride in tetrahydrofuran. After 2 hours the ice cooled solution was carefully quenched by the addition of 5 mL of 10% sodium hydroxide and the resulting suspension was filtered through CELITE®. The filtrate was dried over magnesium sulfate filtered and concentrated to yield 2.7 grams of β-(4-methoxyphenyl-sulfonyl)-D,L-alaninol.

Provenance & Evidence