Triphenylphosphine → HCID 7019602, compound

Participants

Reaction Conditions

Reaction Steps

2.44 g (12.05 mmol) of diisopropyl azodicarboxylate are added dropwise, at 0° C., to a solution of 3.16 g (12.05 mmol) of triphenylphosphine in 30 ml of tetrahydrofuran. Once the addition is complete, the mixture is stirred for 30 minutes at this temperature. The reaction medium is cooled to -10° C. and a solution of 1.45 g (8.05 mmol) of (S)-2-benzyl-3-hydroxypropionic acid (X S) and 0.92 g (12.05 mmol) of thioacetic acid in 10 ml of tetrahydrofuran is added dropwise. Once the addition is complete, the mixture is stirred for one hour at -10° C. and for a further two hours at room temperature.

Provenance & Evidence