HCID 10879523, compound → HCID 11106580, compound

Participants

Reaction Conditions

Reaction Steps

130 mg of lipase obtained from Pseudomonas fluorescens (Fluka) are added to 0.25 g (1 mmol) of 2-benzyl-1,3-propanediol diacetate (VIII) above dissolved in a mixture of 9.9 ml of acetone and 23.1 ml of phosphate buffer pH=7, and the medium is then heated at 30° C. for 48 hours. The solution is then extracted with ethyl ether (twice 20 ml). The ether phases are combined, dried over magnesium sulphate, filtered and concentrated under vacuum. The residue is purified by chromatography on silica (7/3 ethyl ether/petroleum ether eluent). 80 mg of oil are obtained.

Provenance & Evidence