Thionyl Chloride → 2-Acetylthiomethyl-3-phenyl-propionyl chloride

HRID 849706Notes

Reaction equation

[C:1]([S:4][CH2:5][C@@H:6]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7](O)=[O:8])(=[O:3])[CH3:2].S(Cl)([Cl:19])=O>>[C:1]([S:4][CH2:5][CH:6]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7]([Cl:19])=[O:8])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 7408367HCID 7408367, compound

Product 1

HCID 103777342-Acetylthiomethyl-3-phenyl-propionyl chloride

Procedure

(S)-2-Acetylthiomethyl-3-phenylpropanoic acid (Ia S) (Example 2, stage e) is treated with thionyl chloride according to the same procedure as that described in Example 3, stage f.

Sources & evidence

ORD record: ord-a0add61c53bb4480a5789a3d1f78f0ab
Source dataset: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06013829

Reaction notes

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