反应详情

A solution of 4-methyl-2-methylenepentanoic acid (3.5 g) and O-benzylhydroxylamine were heated at 1200 for 8 h. The reaction mixture was then partitioned between 50 mL of 1.0 N NaOH and 50 mL of diethyl ether. The aqueous portion was separated, acidified to pH 3 with 10% HCl and washed with 50 mL of ether. Ion exchange chromatography (Dowex--50W) eluting with 20% pyridine/water gave 2-(benzyloxyaminomethyl)-4-methylpentanoic acid.

1. customThe reaction mixture was then partitioned between 50 mL of 1.0 N NaOH and 50 mL of diethyl ether
2. customThe aqueous portion was separated
3. washwashed with 50 mL of ether
4. washIon exchange chromatography (Dowex--50W) eluting with 20% pyridine/water